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The IT infrastructure at ING Investment Management Middle East is highly secure with business continuity and disaster recovery plans put in place to mitigate any high risk situations. The production servers and infrastructure are currently located at the firm's data centre in DIFC, while the eHDF facility is used as a secondary disaster recovery site.
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In the old days, to build my network marketing business, I was forced to go to the hotel meetings. I didn?t really want to do this, but as my sponsors always said it`s the only thing that works! I remember the days when I made cold calls, inviting friends and family to come to the meetings, but the truth was that nothing ever happened.
Is this something you can relate to? When I played around with the idea that there had to be something better than this and presented this to my up line, they would just tell me to keep trying and that the law of numbers will play in my favor. One day I decided to strike back, and told myself I`ve had enough. From this day on I decided I was going to promote my network marketing business online.
Most network marketers never make an attempt to take their business online. The sole reason is that they have not been taught this way. I can only be thankful for the day I went on my own, because I found out the real difference between online and offline marketing. I won`t lie to you, cold calling, passing out flyers and going to hotel meetings may work. But just remember, 97% of all network marketers fail miserably, and I found a big reason why.
There is one crucial difference in online and offline marketing. The fear of rejection is erased from the face of the earth when you market online. When you communicate to people face to face, you always worry what they will have to say to you. But when you communicate through electronic devices such as computers and through a network like the internet, this fear is simply gone.
At the same time, Internet does offer huge benefits.
It gives you the capacity to brand yourself as a leader and authority. This way you use attraction marketing, which aids your struggle in building your network marketing business online. There are several ways of online network marketing to communicate your message.
There`s a large number of video sharing sites offer hosting for free. Article marketing is one other method.You can also use email marketing, forum marketing, craigslist, classifieds or even ebay. The reason your upline won`t tell you this, is that they do not know it. Network marketing online brings in huge benefits for you, if you can learn how to do it properly.
About the Author
Raj Arvin is a renowned Internet marketing coach and industry leader who is creating abundance in all dimensions of his life including finances and helping others to achieve the same.Tune in for his Daily marketing Tips, Techniques and Strategies. He teaches on How To use the Internet to create LASTING Success. If you want to learn How To create Prosperity and Affluence in all aspects of your life, welcome to http://www.GoForGoldmine.com
I miss playing Superhero RPG's, and I was never really interested in those "teenager/children of" superhero type RPGs. Original Superhero characters would be best, but canon is cool too.
There will also be some twists and turns in the RPG.
Plot:
An alternative Marvel universe RPG
Most of the Superhero's are off fighting a battle somewhere out in the universe, there are only a handful of Superheros still on Earth. Gotham City was nearly completely destroyed by an earthquake and now the hero's must pick up the pieces. In the middle of this difficult task another threat appears on Earth, now the hero's try and save the city while battling a superior force of Sentinel robots.
Under a new proposal to expand the FishHawk Sports Complex, the soccer program will get the fields it desperately needs, protected gopher tortoises will get a new home and Starling residents will get peace and quiet.
Hillsborough County Parks, Recreation and Conservation director Mark Thornton outlined the plan at a meeting at the Palmetto Club Wednesday night where a show of hands indicated residents approved of the concept.
In an agreement hashed out with the help of FishHawk Ranch developer Newland Communities, the parks department plans to add four new soccer fields north of the existing complex on 20 acres currently owned by Newlands Communities and designated for conservation.
In exchange, the property dedicated to the county west of the complex, abutting the Starling subdivision, would become a conservation lot with a dedicated habitat for gopher tortoises.
The county also negotiated a deal with the Hillsborough County School District to upgrade two playing fields behind Randall Middle School to the east of the sports complex and add lighting so they can be used by the community's soccer and lacrosse clubs.
Before proceeding, the plan requires state approval to amend the Development of Regional Impact for FishHawk Ranch.
But, if all goes well, Thornton said construction of the four new fields could begin in 18 months. In the meantime, the parks department will go ahead and add lighting to the fields behind Randall in time for the FishHawk Lacrosse program to use them in January.
"With this plan, we think the construction costs will be lower and it's much more user-friendly," said Thornton. "I'm excited about the plan."
Starling residents were equally thrilled.
Under the county's original proposal, the soccer fields would have backed up to homes in the neighborhood.
"Thank you, thank you, thank you," said Jeff Dunlap, one of those residents whose home backs up to the property.
"This demonstrates that the process really does work," said Starling resident Jim Inguagiato. "Our voices were heard."
The proposal also received a thumbs up from residents whose children play sports at the FishHawk Sports Complex.
"It's a win-win for everybody," said resident Steve Hayes.
"This will give us the additional space we need," said Joe Kurtz, president of the FishHawk Soccer Club, which has 1,600 players. He said the soccer club is already using the fields behind Randall but must rent light towers to light the fields at night.
With the approval of the residents, Thornton said the county will begin working on the DRI amendment for FishHawk Ranch and the preliminary engineering.
The county also will look into adding turn lanes into the sports complex to make it easier for Starling residents to turn left out of their neighborhood.
The $2.8 million expansion project is being funded with impact fees.
ARTS &?ENTERTAINMENT Thursday, October 25, 2012 The Dalles Chronicle
Submit items to Arts & Entertainment by e-mail at kursprung@thedalles chronicle.com, by fax at 541-298-1365, or at The Chronicle office, 315 Federal St., The Dalles.
This Week ???? Oct. 25 ? Kathy Mattea, 8 p.m., Columbia Gorge Interpretive Center, tickets: http://bit.ly/I3fZoQ ???? Oct. 26 ? Dance at the log house, 7 p.m., Highway 197, Dallesport ???? Oct. 26 ? Tony Furtado and Luke Price, 9:30 p.m., Cebu Lounge, Hood River Inn, 1108 E. Marina Way, Hood River,? www.hoodriverinn.com ???? Oct. 26-28 ? Mt. Hood Independent Film Festival, Columbia Center for the Arts, 215 Cascade Ave., Hood River, 541-387-8877, ext. 117, www.columbiaarts.org ???? Oct. 26-27 ? Halloween Disco and Hip Hop Party, The Vault, 9 p.m., 209 E. Second St., The Dalles ???? Oct. 27 ? Pet Halloween Costume, 3 p.m., Coastal Farm & Ranch, 2600 W. Sixth St., The Dalles ???? Oct. 27 ? Free 1960s Halloween and Dance Party with The Sceptres, a benefit for The Dalles Civic Auditorium, doors open 6:30 p.m., show at 7:30 p.m., 21 and older at the Civic, Fourth and Federal streets. ???? Oct. 27 ?Aaron Meyer and Tim Ellis with Columbia Gorge Sinfonietta, 7:30 p.m., Hood River Middle School ???? Oct. 27 ? Hallowine at the haunted Sunshine Mill, 7-11 p.m., 901 E. Second St., The Dalles, www.sunshinemille.com, 541-298-8900 ???? Oct. 27 ? Dungeons and Dragons Demo, noon-4 p.m., Hood River Hobbies, 110 Fourth St., Hood River, www.hoodriverhobbies.com ???? Oct. 27 ? The Police Cars, 9:30 p.m., Cebu Lounge, Hood River Inn, 1108 E. Marina Way, Hood River, www.hoodriverinn.com ???? Oct. 27-28 ? Heirloom Apple Celebration, www.hoodriverfruitloop.com, or call 541-386-7697 ???? Oct. 27-28 ? Happy Hallow-wine, Maryhill Winery, www.maryhillwinery.com ???? Oct. 28 ? Columbia Gorge Marathon and Gorge Kids? Marathon, Hood River, www.columbiagorgemarathon.com ???? Oct. 28 ? Jam and Pie Social, 2 p.m., Mid-Columbia Senior Center, 1112 W. Ninth St., The Dalles ???? Oct. 28 ? Magic the Gathering Game Day, 3:30-7:30 p.m., Hood River Hobbies, 110 Fourth St., Hood River, www.hoodriverhobbies.com, 541-386-1223 ???? Oct. 29 ? Por el Flamenco, 7:30-9:30 p.m., Columbia Gorge Community College The Dalles Campus, www.savannahfuentes.com ???? Oct. 30 ? For the Good Times, 7-9 p.m., free or donation, Mid-Columbia Senior Center, 1112 W. Ninth St., The Dalles ???? Oct. 30 ? Oregon Poet Laureate Paulann Petersen, 1-5 p.m., free, Columbia Gorge Community College Hood River Campus, www.oregonpoetlaureate.org ???? Oct. 31 ? Downtown Trick or Treat, 3-5 p.m., downtown The Dalles ???? Oct. 31 ? Safe Halloween, 7 p.m., Flagstone Senior Living, 3325 Columbia View Dr., The Dalles ???? Oct. 31 ? Safe Halloween, 5 p.m., downtown Hood River ???? Oct. 31 ? Strawberry Mountain Band, 11 a.m., White Salmon Senior Center Upcoming ???? Nov. 1 ? ?Nanda: The Jacket? music and dance performance, 7:30 p.m., Hood River Middle School, 1602 May St., Hood River, tickets $20 for adults, $15 for students and seniors, $12 for children 11 and younger, www.columbiaarts.org ???? Nov. 2 ? Willy & Nelson, 6-9 p.m., Zim?s Brau Haus, 604 E. Second St., The Dalles ???? Nov. 9 ? Les Vaughn and the Fenderbender, 6-9 p.m., Zim?s Brau Haus, 604 E. Second St., The Dalles ???? Nov. 10 ? Tingstad & Rumbel, 8 p.m., Columbia Gorge Interpretive Center, tickets: http://bit.ly/I3fZoQ ???? Nov. 16 ? Willy & Nelson, 6-9 p.m., Zim?s Brau Haus, 604 E. Second St., The Dalles ???? Nov. 17 ? Holiday Cooking & Cocktails, 3-5 p.m. and 506 p.m., Skamania Lodge, (509) 427-7700, www.skamania.com ???? Nov. 17 ? Crazy 8?s authors? tour featuring 28 Oregon Authors, Klindt?s Booksellers, The Dalles ???? Nov. 22 ? Community Thanksgiving Dinner ???? Nov. 23 ? Starlight Parade
Regular events: ???? First Friday: First Friday of each month, downtown Hood River ???? Second Saturday at WAAM (Western Antique Aeroplane and Automobile Museum), www.waaamuseum.org ???? Gorge Grown Farmers? Market: Thursday, Hood River Middle School, 1602 May St., 4-7 p.m., May 3-Nov. 15
If anyone is going to get their hands on new Nexus hardware first, it's going to be Google top-brass. So when photos from Senior Vice President of Engineering, Vic Gundotra, show up on his Google + with "Nexus 10" in the details, we pay attention. The pictures show some idyllic scenes from the beach, but what we're all interested in is the EXIF data. So, 2,046 by 1,536 you say? That's 3-megapixel by our calculations, which may not be the true original resolution of the image of course. With a big Google event just around the corner, though, we imagine we won't have to wait long to find out more.
Cancers arise in the body all the time. Most are nipped in the bud by the immune response, not least by its T cells, which detect telltale molecular markers?or antigens?on cancer cells and destroy them before they grow into tumors. Cancer cells, for their part, evolve constantly to evade such assassination. Those that succeed become full-blown malignancies. Yet, given the right sort of help, the immune system can destroy even these entrenched tumors.
In the October 22nd issue of the Journal of Experimental Medicine, researchers led by Jedd Wolchok, MD, PhD, of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York describe one way in which that might be achieved. The paper relates how the cancer drug cyclophosphamide (CTX) and OX86?an antibody that activates a molecule named OX40 on T cells?were combined with a cutting-edge therapy known as adoptive T cell transfer to eradicate advanced melanoma tumors in mice.
Wolchok and his colleagues had previously shown that CTX and OX86 treatment caused the regression of such tumors. Now they wanted to see if adding T cell transfer to the mix would further improve outcomes. T cell transfer is an investigative immunotherapy in which T cells that target tumors are isolated from patients, manipulated, expanded and then transfused back into those patients.
A variety of T cells are of relevance to this approach. One is the CD8+ T cell, which can directly kill diseased and cancerous cells. Another is the CD4+ T cell, whose general role is to orchestrate the immune assault. It comes in several varieties ? examples are the T helper 1 (Th1) and T helper 2 (Th2)?each of which elicits a distinct sort of immune response. And then there is the regulatory T cell, which keeps a lid on the last two responses.
The activation of OX40 on T cells has varying effects. "When OX40 is activated on regulatory T cells in the tumor, they get so stimulated that they actually die," explains Wolchok. Other CD4+ T cells, on the other hand, step up the immune attack following OX40 activation.
To harness that phenomenon, Wolchok's team transplanted melanoma tumors into mice and allowed them to grow until they got to be about as advanced as permitted. They then gave the mice CTX and OX86, waited a day and transfused them with T helper cells engineered to target a tumor antigen known as Trp1.
The results were as surprising as they were swift: tumors expressing the Trp1 antigen didn't just get smaller. They were eradicated. What's more, the combination therapy also destroyed tumors composed of a mix of cells that display the Trp1 antigen and those that do not. This is significant because most human tumors are built from such mixed populations of cells.
"These T cells are so exquisitely tuned," says Wolchok, "that they induce collateral damage to cells in the tumor that don't even express the targeted antigen."
Wolchok and his colleagues discovered that OX40 activation dramatically altered the transfused T helper cells. They remained CD4+ T cells, yet became capable of destroying cancer cells themselves. Further, they took on traits common to long-lived memory cells, which ensure that any future tumors expressing the targeted antigen are quickly destroyed. Finally, these entirely novel T cells also had qualities of both Th1 and Th2 subtypes of T helper cells. This might explain how they induced an anti-tumor response vigorous enough to kill tumor cells that did not even bear the antigen they were targeting.
"This is not just of academic interest," says Wolchok, pointing out that most T cell transfer studies have so far focused on CD8+ T cells. "If these killer-memory CD4+ T cells are the ones that are really important to tumor killing then they are the ones we should be trying to transfer."
Further, combining other immunotherapies with OX40-stimulation could by itself boost T cell activity against tumors to significant effect. "Ideally," says Wolchok, "if one could make the endogenous immune response sufficiently robust, you might not need to do the adoptive transfer." That idea could soon be put to the test. Ludwig and the Cancer Research Institute signed an agreement with MedImmune, the global biologics arm of AstraZeneca, that will enable the examination of the clinical effects of an OX40-activating antibody as well as two other antibodies that disrupt the suppression of immune responses by tumors.
The new findings on how OX40 activation affects T helper cells will doubtless inform those studies.
###
Ludwig Institute for Cancer Research: http://www.licr.org
Thanks to Ludwig Institute for Cancer Research for this article.
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A holistic approach for assessing and matching skills to appropriate levels of scale for
sustainability - in agriculture, business, and in life.
Join Shane J. LaBrake for a 3-day intensive workshop that blends philosophy and pragmatic advice with hands-on training and real-life problem solving as you develop your small-scale agricultural endeavors.? Based on lessons learned from a lifetime of work and travel in food and farming, Shane provides unique insights from his practical experience of reconciling idealism with the nitty-gritty, day-to-day reality of maintaining a viable and sustainable enterprise. ?As we consider small farm design, we will address real life skills and knowledge that aspiring farmers need to know. On-site and hands-on demonstrations with scale-appropriate tools, equipment, and gear will allow workshop attendees to make better decisions for their own operations. Classroom lectures and discussions will explore the rhythm and evolution of a season, and offer tips and ideas for better management of time and resources. ?Shane's unique approach will leave you informed and empowered.? He encourages holistic thinking and rational problem solving as opposed to hasty decisions based on emotion and circumstance.
"Design is the first signal of human intention." -??William McDonough
This class encourages thinking to clarify intention, and challenges the participants to create designs that will work for them.
Please dress for the weather and be prepared to be challenged and engaged.
A binder of readings and other resource materials will be provided to each participant.
The Coastal collection fits today's casual lifestyle. Recessed doors, bead board panels and solid wood mouldings provide a clean, contemporary style that is complemented by a choice of painted or rich stained finishes
Great news for anyone who's lusted after the gorgeous retina display on the MacBook Pro—but has been hesitant to drop $2,200 or make room for a 15-inch laptop. Apple has officially announced a 13-inch version of its portable workstation, with a 2560 x 1600 Retina Display. That's just a slight drop in resolution from the 15-incher. More »
A rodeo man, a Chinese teacher and a congressman walk into a preschool. They?re greeted uniformly ? ?ni hao!?
No, it isn?t the start of a bad joke or worse movie script. It?s Friday at the River Hills Community Church preschool, where dozens of students are learning a language some feel will be critical to their success. ?Ni hao? means ?hello? in Chinese.
?They?re going to be great ambassadors for us for many years to come,? said Carrie Tucker, who, along with husband Richard, helped establish a Chinese curriculum at the preschool. ?[Speaking] Chinese is the future for our country and for our young people.?
The Tuckers live in River Hills but travel throughout China for rodeo and other business events. They?ve also partnered in recent years with Furman University to provide scholarships through its Asian Studies Department. Their goal is to have Chinese taught in public schools by the time at least some of the preschoolers in the new program begin first grade.
?This is a small way to get started,? Carrie Tucker said. ?If we don?t equip our children to be competitive, we all lose.?
The idea behind Chinese instruction is that industrialization there will increase opportunities for Americans versed in the language and culture. Chinese children are required to learn English, and the Tuckers hope efforts such as the one at the church preschool will help local children keep pace.
U.S. Rep. Mick Mulvaney, R-Indian Land, chatted with students and staff at the ribbon-cutting event Friday. Competition in a global workforce is at or near the point of requiring proficiency in at least one foreign language already, he said. Otherwise, would-be workers put themselves at a ?tremendous disadvantage.?
?The opportunities that will open to these children because of this program are immeasurable,? he said.
Educational opportunities are at stake, too.
Annually, the Tuckers look for students willing to study in China for scholarships, and they aren?t the only ones.
?They?re begging people who know Chinese to come, to further their education,? Richard Tucker said of schools there.
Ke Wang instructs about 40 children once a week, and the program could expand to daily lessons. The 4-year-olds will learn colors, shapes and numbers, along with cultural lessons. Students already have some basic greetings down in the first couple of weeks.
Wang does get some interesting feedback, such as the first time she told one student that the class would be learning Chinese.
?I don?t like Chinese,? Wang recalled the student saying. ?I like pizza better.?
Church music director Kevin Gray, also music leader for the preschool, plans to teach Chinese music when possible. Music can be the ?universal language,? he said, and students can learn of instruments and scale structures used in China.
?I haven?t learned to sing in Chinese yet,? Gray said.
Students are taking basic steps, and leaders say the key is to promote opportunities as they grow, such as Chinese in public schools throughout the county and state. The church hopes that its preschool program could be an example for others looking to implement something similar.
[unable to retrieve full-text content]PubCon live blogging recap of Jabez Lebrett on Psychology of Facebook Conversion and Dan Zarella on The Science of Inbound Marketing. ... The Psychology and Science Behind Inbound Marketing. by Kelsey_Libert on October 23, 2012. Wrapping up the first day at PubCon, ... Facebook is kinda like the Jersey Shore, linguistically, the most shareable content is sexual, positive, learning, media, work constructive, and self reference. The least is negative, leisure, anxiety, numbers.
Justin Timberlake says his nuptials to longtime girlfriend Jessica Biel was “magical”. The singer/actor, 31, tied the knot with the “Total Recall” actress, 30, in [...]
Clue to cause of Alzheimer's dementia found in brain samplesPublic release date: 22-Oct-2012 [ | E-mail | Share ]
Contact: Julia Evangelou Strait straitj@wustl.edu 314-286-0141 Washington University School of Medicine
Researchers at Washington University School of Medicine in St. Louis have found a key difference in the brains of people with Alzheimer's disease and those who are cognitively normal but still have brain plaques that characterize this type of dementia.
"There is a very interesting group of people whose thinking and memory are normal, even late in life, yet their brains are full of amyloid beta plaques that appear to be identical to what's seen in Alzheimer's disease," says David L. Brody, MD, PhD, associate professor of neurology. "How this can occur is a tantalizing clinical question. It makes it clear that we don't understand exactly what causes dementia."
Hard plaques made of a protein called amyloid beta are always present in the brain of a person diagnosed with Alzheimer's disease, according to Brody. But the simple presence of plaques does not always result in impaired thinking and memory. In other words, the plaques are necessary but not sufficient to cause Alzheimer's dementia.
The new study, available online in Annals of Neurology, still implicates amyloid beta in causing Alzheimer's dementia, but not necessarily in the form of plaques. Instead, smaller molecules of amyloid beta dissolved in the brain fluid appear more closely correlated with whether a person develops symptoms of dementia. Called amyloid beta "oligomers," they contain more than a single molecule of amyloid beta but not so many that they form a plaque.
Oligomers floating in brain fluid have long been suspected to have a role in Alzheimer's disease. But they are difficult to measure. Most methods only detect their presence or absence, or very large quantities. Brody and his colleagues developed a sensitive method to count even small numbers of oligomers in brain fluid and used it to compare amounts in their samples.
The researchers examined samples of brain tissue and fluid from 33 deceased elderly subjects (ages 74 to 107). Ten subjects were normal no plaques and no dementia. Fourteen had plaques, but no dementia. And nine had a diagnosis of Alzheimer's disease both plaques and dementia.
They found that cognitively normal patients with plaques and Alzheimer's patients both had the same amount of plaque, but the Alzheimer's patients had much higher oligomer levels.
But even oligomer levels did not completely distinguish the two groups. For example, some people with plaques but without dementia still had oligomers, even in similar quantity to some patients with Alzheimer's disease. Where the two groups differed completely, according to Brody and his colleagues, was the ratio of oligomers to plaques. They measured more oligomers per plaque in patients with dementia, and fewer oligomers per plaque in the samples from cognitively normal people.
In people with plaques but no dementia, Brody speculates that the plaques could serve as a buffer, binding with free oligomers and keeping them tied down. And in dementia, perhaps the plaques have exceeded their capacity to capture the oligomers, leaving them free to float in the brain's fluid, where they can damage or interfere with neurons.
Brody cautions that, due to the difficulty in getting samples, oligomer levels have never been measured in living people. Therefore, it's possible these floating clumps of amyloid beta only form after death. Even so, he says, there is still a clear difference between the two groups.
"The plaques and oligomers appear to be in some kind of equilibrium," Brody says. "What happens to shift the relationship between the oligomers and plaques? Like much Alzheimer's research, this study raises more questions than it answers. But it's an important next piece of the puzzle."
This study was supported by the National Institutes of Health (NIH), a Burroughs Wellcome Career Award in the Biomedical Sciences, the Thrasher Research Fund, the National Institute on Aging, the Charles F. and Joanne Knight Alzheimer's Disease Research Center at Washington University, the Cure Alzheimer's Fund, and the NIH Neuroscience Blueprint Core Grant to Washington University. Grant numbers: NIH R01 NS065069, NIH K08 NS049237, NIH AG13956, NIH AG029524, NIH K-23-AG03094601, NIH R-01-NS065667, NIH P50-AG05681, NIH P30 NS057105, and NIH P01-AG03991. Human brain and CSF samples were provided by the Washington University Knight Alzheimer's Disease Research Center.
Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Clue to cause of Alzheimer's dementia found in brain samplesPublic release date: 22-Oct-2012 [ | E-mail | Share ]
Contact: Julia Evangelou Strait straitj@wustl.edu 314-286-0141 Washington University School of Medicine
Researchers at Washington University School of Medicine in St. Louis have found a key difference in the brains of people with Alzheimer's disease and those who are cognitively normal but still have brain plaques that characterize this type of dementia.
"There is a very interesting group of people whose thinking and memory are normal, even late in life, yet their brains are full of amyloid beta plaques that appear to be identical to what's seen in Alzheimer's disease," says David L. Brody, MD, PhD, associate professor of neurology. "How this can occur is a tantalizing clinical question. It makes it clear that we don't understand exactly what causes dementia."
Hard plaques made of a protein called amyloid beta are always present in the brain of a person diagnosed with Alzheimer's disease, according to Brody. But the simple presence of plaques does not always result in impaired thinking and memory. In other words, the plaques are necessary but not sufficient to cause Alzheimer's dementia.
The new study, available online in Annals of Neurology, still implicates amyloid beta in causing Alzheimer's dementia, but not necessarily in the form of plaques. Instead, smaller molecules of amyloid beta dissolved in the brain fluid appear more closely correlated with whether a person develops symptoms of dementia. Called amyloid beta "oligomers," they contain more than a single molecule of amyloid beta but not so many that they form a plaque.
Oligomers floating in brain fluid have long been suspected to have a role in Alzheimer's disease. But they are difficult to measure. Most methods only detect their presence or absence, or very large quantities. Brody and his colleagues developed a sensitive method to count even small numbers of oligomers in brain fluid and used it to compare amounts in their samples.
The researchers examined samples of brain tissue and fluid from 33 deceased elderly subjects (ages 74 to 107). Ten subjects were normal no plaques and no dementia. Fourteen had plaques, but no dementia. And nine had a diagnosis of Alzheimer's disease both plaques and dementia.
They found that cognitively normal patients with plaques and Alzheimer's patients both had the same amount of plaque, but the Alzheimer's patients had much higher oligomer levels.
But even oligomer levels did not completely distinguish the two groups. For example, some people with plaques but without dementia still had oligomers, even in similar quantity to some patients with Alzheimer's disease. Where the two groups differed completely, according to Brody and his colleagues, was the ratio of oligomers to plaques. They measured more oligomers per plaque in patients with dementia, and fewer oligomers per plaque in the samples from cognitively normal people.
In people with plaques but no dementia, Brody speculates that the plaques could serve as a buffer, binding with free oligomers and keeping them tied down. And in dementia, perhaps the plaques have exceeded their capacity to capture the oligomers, leaving them free to float in the brain's fluid, where they can damage or interfere with neurons.
Brody cautions that, due to the difficulty in getting samples, oligomer levels have never been measured in living people. Therefore, it's possible these floating clumps of amyloid beta only form after death. Even so, he says, there is still a clear difference between the two groups.
"The plaques and oligomers appear to be in some kind of equilibrium," Brody says. "What happens to shift the relationship between the oligomers and plaques? Like much Alzheimer's research, this study raises more questions than it answers. But it's an important next piece of the puzzle."
This study was supported by the National Institutes of Health (NIH), a Burroughs Wellcome Career Award in the Biomedical Sciences, the Thrasher Research Fund, the National Institute on Aging, the Charles F. and Joanne Knight Alzheimer's Disease Research Center at Washington University, the Cure Alzheimer's Fund, and the NIH Neuroscience Blueprint Core Grant to Washington University. Grant numbers: NIH R01 NS065069, NIH K08 NS049237, NIH AG13956, NIH AG029524, NIH K-23-AG03094601, NIH R-01-NS065667, NIH P50-AG05681, NIH P30 NS057105, and NIH P01-AG03991. Human brain and CSF samples were provided by the Washington University Knight Alzheimer's Disease Research Center.
Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.
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As if the hot mess of a life that this girl has could get any hotter. well, it finally has. Reports that some kind of crazy intervention was carried out on her, only to be foiled have hit the web. We’ve heard that her father tried to stage some sort of intervention that was quashed by Lindsay herself who called the cops on her fame-whoring father. This report came just a week or so after the story that she blew through nearly $50,000 worth of mayhem and partying on a tab at the Chateau. That bill actually nearly landed her in court after she refused to pay it. Fast forward a few weeks… At first it sounded like this was yet another student by Michael Lohan. But TMZ has began to dig up some proof that it was much ore than that. The site says that her entire team, including her attorneys were on board and thought that she needed an emergency intervention. Check out some excerpts from what TMZ claims are emails sent by Micheal Lohan to members of team LiLo: “(I’ve heard she is) drinking between a bottle and a bottle and a half of vodka per day…I [...]
FILE - This Jan. 11, 2012 file photo shows actor Chris Bauer arriving at the world premiere of "The Grey" in Los Angeles. Bauer, who portrays Sheriff Andy Bellefleur on the popular HBO series "True Blood," will star in a production of ?What Rhymes with America? by Melissa James Gibson. Previews begin Nov. 19. The play opens Dec. 12 in new York. (AP Photo/Katy Winn, file)
FILE - This Jan. 11, 2012 file photo shows actor Chris Bauer arriving at the world premiere of "The Grey" in Los Angeles. Bauer, who portrays Sheriff Andy Bellefleur on the popular HBO series "True Blood," will star in a production of ?What Rhymes with America? by Melissa James Gibson. Previews begin Nov. 19. The play opens Dec. 12 in new York. (AP Photo/Katy Winn, file)
NEW YORK (AP) ? "True Blood" star Chris Bauer is going to be sinking his teeth in a new play in New York.
The Atlantic Theater Company said Thursday that Bauer will star in a production of "What Rhymes With America" a new work by by Melissa James Gibson.
Bauer, who also was on NBC's "Third Watch" and the Billy Crystal movie "61(asterisk)," said in a phone interview from Los Angeles that he was desperate to hit the stage again.
"I've told my children to think of this as though I'm going for a life-saving operation," he said. "The opportunity to work on a play from the ground up in my favorite theater with all new people, makes me feel like there's a real potential for reinvigoration."
The cast also includes Aimee Carrero, who currently stars on the Cartoon Network live-action series "Level Up"; Seana Kofoed, on Broadway in "Proof" and "Night Must Fall"; and Da'Vine Joy Randolph, who earned a Tony Award nomination for "Ghost: The Musical."
It will be directed by Daniel Aukin, who recently staged Joshua Harmon's play "Bad Jews" and Sam Shepard's "Heartless" off-Broadway and "4000 Miles" by Amy Herzog at Lincoln Center. Previews of "What Rhymes With America" begin Nov. 19. The play opens Dec. 12.
Bauer, a company member of the Atlantic Theater Company, has appeared in three Jezz Butterworth's plays at the Atlantic ? "The Night Heron," ''Parlour Song" and "Mojo."
Bauer, 45, plays Detective Andy Bellefleur in "True Blood" and is known for his role as union boss Frank Sobotka on the TV series "The Wire." He made his Broadway debut in "A Streetcar Named Desire" in 2005.
Bauer said the new play is about a father's attempt to connect with his estranged daughter. All the characters, he said, "are desperately trying to connect and have an impact on their world, and no one's noticing." Gibson, a staff writer on the FX show "The Americans," also wrote the play "This."
Bauer was last on stage in 2010 doing David Mamet's "Romance" at the Bay Street Theater in Sag Harbor. Though it had a short run, "it was long enough for me to see how totally out of shape I was," he said laughing.
"There's a level of fitness that's required to give an audience what they deserve. You just do not get the strength in those muscles on television."
The Coast Guard and the National Oceanic and Atmospheric Administration seized nearly 8,000 pounds of allegedly illegally caught fish from a longline fishing boat in Dulac this week. The crew of the 62-foot fishing vessel "Blue Fin'' on Tuesday was allegedly using live bait, a practice that is illegal in the Gulf of Mexico pelagic longline fishery because often sea turtles are more enticed by live bait so will take it, become trapped and drown, according to Mark Kinsey, National Oceanic and Atmospheric Administration's assistant special agent in charge of enforcement for Texas and Louisiana.
The vessel also was cited for not having proper sea turtle release gear on board, for having specific gear to catch htheir live bait - bigeye cad - and for having J-hooks on board, a type of hook that goes further down a fish's throat than legal circle hooks, Kinsey said. The boat was fishing approximately 90 miles off the coast of Louisiana, where about half a dozen similar cases are discovered each year.
The seized catch included 7,133 pounds of yellowfin tuna; 535 pounds of oilfish; 220 pounds of wahoo; and 44 pounds of mahi-mahi. The Coast Guard said the catch was worth more than $20,000. NOAA Fisheries Service will determine if a formal notice of violation is to be issued.
Fishing with live bait is prohibited in the Gulf of Mexico pelagic longline fishery, as the fishing lines, which extend for about 30 to 40 miles with an average about 750 hooks, are often left in the water for days or weeks before fishermen check them. The amount of hooks, along with the time they are left out there, means that turtles and other animals can more easily drown if they are caught.
There are five species of sea turtles inhabiting the Gulf of Mexico and the Atlantic Ocean, and all are protected under the Endangered Species Act.
In addition to turtles, Kinsey says that billfish, which include sailfish, spearfish and marlin, also often get killed on such lines. Billfish, a highly migratory species that is severely depleted, are often caught as bycatch in commercial tuna and swordfish fisheries.
On October 5, President Barack Obama signed the Billfish Conservation Act into law, effectively banning the importation of all billfish into the continental United States. Sen. David Vitter had introduced the legislation in the Senate. There already is a ban on commercial harvest and sale of Atlantic?caught billfish but the new act bans the sale of Pacific-caught billfish. Swordfish are not considered billfish by fisheries managers.
"Louisiana is known as the sportsman's paradise and we understand that it's important to protect this majestic species, a real prize of recreational fishing," Vitter said of the billfish legislation following its passage
Remember the rumors of a new HTC flagship Android phone that started making the rounds last month? The ones bolstered by questionable leaked image after questionable leaked image? As it happens, the device that inspired all those rumors ? now known as the HTC J Butterfly ? was officially revealed at a recent press event in Tokyo, and it seems just as impressive as the rumors made it out to be.
The shuttle Endeavour dodged plenty of space junk zipping around Earth.
The question Saturday, though, was would its wing avoid an apartment building on narrow Crenshaw Drive? Could it gingerly pivot around tall pines planted in honor of the Rev. Martin Luther King Jr.? Would the streets of Inglewood and Los Angeles buckle under the weight of the 170,000-pound orbiter and its massive transport vehicle?
After months of meticulous planning, those were among the myriad challenges confronting hundreds of workers who escorted Endeavour on the last leg of its 12-mile journey to the California Science Center, where it will be displayed.
Planners appeared to get the engineering right but not the timing. What began as a head start in the morning turned into an ever-increasing delay by night. As crowds waited along the route, officials said the shuttle would be several hours late to its destination, probably arriving sometime Sunday morning.
Endeavour's 26th and final mission came down to sweating the details. Engineers had mapped its route and possible obstructions down to the millimeter. Crews swarmed around the spacecraft like a court of handmaidens Saturday, taking down streetlights and signs, removing power lines and trimming trees.
"We've been planning for this day for six months," said Southern California Edison worker Michael Fuller. "But a plan is what you do to help you sleep at night. What counts is what we do on the fly during the big event."
After being towed by a pickup truck across a bridge spanning the 405 Freeway late Friday night, the shuttle's epic last commute resumed shortly after 6 a.m. Saturday.
Inching along at a top speed of 2 mph, the five-story-tall Endeavour dwarfed everything in its path, its black nose announcing itself like a curious puppy moving through a miniature diorama.
Thousands of cheering onlookers packed sidewalks, parking lots and rooftops along the spacecraft's route.
Endeavour made a two-hour stop at the Forum in Inglewood, arriving early to the delight of crowds and politicians who crowed about Southern California landing what they called a national treasure.
"Endeavour was born here," state Sen. Roderick Wright (D-Inglewood) said. "This morning ... we have the opportunity to say, 'Welcome home.'"
The rest of the day was a game of inches as Endeavour wriggled, pitched and scooted its way across town.
"All the stuff we move is big, heavy stuff," said Steve Mitchell, one of a team of drivers who piloted the computerized 160-wheel transporter that carried Endeavour. "But nothing that means as much as this. It's just so special."
After leaving the Forum, the shuttle headed east on Manchester Boulevard but soon came up against an obstacle it wasn't built to deal with.
A tree branch.
The transporter stopped. With the flick of a joystick, its driver turned the huge dolly's wheels sideways and slowly scooted it over. Within a minute, Endeavour was rolling again.
Up ahead, Rand Brooks had been working since midnight to further widen one of Endeavour's tightest fits ? a curving stretch of Crenshaw Drive where the orbiter's 78-foot wingspan crossed over lawns and driveways and came within a hair's breadth of several buildings.
Crews had placed 400 tons of compacted material on the street to keep the shuttle level with the islands at the intersection with Crenshaw Boulevard and give it more room.
"It's pretty exciting," Brooks said, grateful to be involved. "It's a once-in-a-lifetime opportunity."
As the shuttle approached the turn from Manchester onto Crenshaw Drive, police ushered the crowd back.
The current economic situation has led people to search for other opportunities. Many have heard of network marketing, and are looking for more information about the potential of starting a Shaklee home business. Shaklee is one of many network marketing companies out there that claim that you can earn a full time income from selling their products while teaching others to do the same. In this article, we will look at the company a little closer, and tell you if this home business opportunity is legit.
A Little Company Info
Shaklee was founded in 1956, by Dr. Forrest Shaklee. With a vision slightly before it's time, Dr. Shaklee created Vitalized minerals, which was based on providing nutritional supplements through what is know today as multi vitamins. Since then, Shaklee Corporation has expanded their product line to nutritional supplements, weight management, sports nutrition, aging, cleaning, and beauty products. All of their products are 100% all natural, and they are at the forefront of the "green" movement in an attempt to make the planet a healthier place. In the process of expansion and research, Shaklee has since become the #1 Natural Nutrition Company in the United States. This article is not intended to give a full company review, so we will stop here and elaborate on this in another article. My intention is to show you that Shaklee has been around successfully doing business for a very long time now.
With this being said, can you build a Shaklee home business?
The bottom line is this. Anyone can join Shaklee, either as a member to enjoy their excellent products, or as a distributor to enjoy the products, as well as sell them to other people. Is it easy? No. Is it a get rich quick business? No. Is it something you can make a living doing if you put hard work and consistent daily effort in to? Absolutely!
Shaklee will not make claims that you can build a business on auto pilot. The company is very ethical, and will flat out tell you that this earning opportunity is not for everyone. Shaklee is looking for hard working people, that enjoy teamwork, working hard, and are concerned about the health of others and the planet.
With all other network marketing companies, to become successful you need to do 2 things:
Sell Products - This will give you a foundation of income to build from. With Shaklee, it is essential that you have a solid customer base to build from. The good news is, the current state of health and healthcare in the United States opens a ton of doors to people looking to take matters into their own hands through prevention.
Sign Up Distributors - This is essential, and if you become good at this, your Shaklee home based business will flourish. In network marketing, the better you become at leading, and teaching others how to be successful the more successful you will become.
These are the 2 things you need to become good at if you want to build a successful Shaklee home business. The truth of the matter is, most all people who attempt to to build a home business with Shaklee fail, however, with the right mindset and hard work it can be done.
Except for the couple of years immediately after the president insisted we needed to go to the moon, where NASA consumed more than 4% of the national budget (but still wasn't very much), it has almost never accounted for a significant part of the budget in any way. For the entire life of the agency, the average budget (in 2007's dollars) has been something like $17,000,000,000/yr.
Hell, since 9/11, we have spent TWICE as much conducting war in the middle east as NASA has spent in its entire fifty-five year live time, in which it developed rocket technology. Developed shuttle technology. Helped improve countless other technologies (including those for the military). Helped generate entire new private industries. Shot a man into space. Shot around the moon. Landed men on the moon several times. Built space-suit-jets for men in space. Conducted space walks. Built a space car. Built and deployed a telescope to see to the beginning of time. Built and manned a space station. Built one (wait, two?) little RC cars that we landed on the surface of Mars. Then built an SUV that we landed on Mars. Not to mention the satellites above our heads. The satellites far out in space, exploring the universe for decades, now. . .
All of that is in *today's* dollars.
So, let's not fool ourselves into believing NASA has ever had a "ton of funding". But, just think what we could accomplish if we blew up a few less brown people or facilitated a few fewer corporate (Haliburtin, KDR, etc) contracts in Afghanistan or Iraq with government resources and just funneled that little bit of money to NASA. Maybe push 5% of that "searchin' for WMDs" money over to NASA. Who knows what fucking amazing shit we could do?
Yeah, yeah, yeah. Private industry yadda yadda. That'd be fine, if we apply that consistently. But if we're going to be debating what's worth funding, how the fuck is pursuing one of the most primitive needs of mankind not near the top of the list?
Instead, we have to bank the whole of our space exploration on the guy who ships books and kindles to your doorstep, the guy behind Doom and Rage, and the guy behind PayPal. Not that there's anything wrong with that, but . . .
The putting out flowers with the valve community features consumed side effects on countless issues with both industrial course of action and also the every day life. Solenoid valve, as a major sort one of the several valves, achieves well with shutting off, releasing, dosing, diffusing as well as combining essential liquids and also gases. The included element is known as the solenoid coil. When this power latest is actually although solenoid coil, that control device can be taken care of to consider effects. Wide job applications happen to be achieved including the substance strength pneumatic as well as hydraulic systems, in which such a valve is actually to manipulate cylinders, fluid electricity motors as well as greater industrial valves.
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Skip Our Review, Click Here For Our TOP rated Opportunity
SFI Marketing Group offers a work at home business opportunity that may work for you.
Updated: We received an e-mail correspondence from a SFI member suggesting our review was in error.
The following lists their current information. We thank the SFI member who contacted us as again our goal is to offer as accurate information as is available on many opportunities as possible.
Hearing direct from those active in these programs is often the best information we can get and is much appreciated.
This is a nice reflection on SFI and what it offers and is summarized below:
SFI Marketing Group, or Six Figure Income, is a marketing company owned by Gerry Carson. It is an affiliate based company with direct marketing; you can also recruit others to earn money on their efforts like many online programs offer.
Once you sign up as an affiliate, you can sell their products.They have nearly a million products. This can be a problem as you are competing with so many other suppliers; it is often better to have your own unique product.
Being an affiliate, you get access to their program information,many materials to assist you in your business, and also a website. The website is ?replicated? which means it is identical to many others that are affiliates in SFI.
There are draw backs to this kind of website including your site is not unique and it often isn?t something that will get found on search engines.
There are other concerns which are outlined in the marketing I have learned. Send me an e-mail and I will offer you some additional things you might want to be aware of regarding these type of web sites.
The levels of involvement are Affiliate, Executive Affiliate, and Team Leader.
You can make higher commissions and other bonuses by becoming an Executive Affiliate (EA) which you can become after making a certain number of sales- this via your own purchases, retail sales or from your downline.
New members are encouraged to purchase a membership to the International Association of Home Business Entrepreneurs (IAHBE) for $29 monthly. This is the simplest way to achieve the EA status, but this is not in any way a requirement or the only way to obtain this status.
The key to most any online program is how easy you can make your sales. Most leads sources do not work, or you need to cold call them to close sales so ask that of your SFI sponsor before you join?.get specific details!
SFI Marketing Group offers an opportunity to participate in the exciting world of internet marketing.
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The Coastal collection fits today's casual lifestyle. Recessed doors, bead board panels and solid wood mouldings provide a clean, contemporary style that is complemented by a choice of painted or rich stained finishes
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Public release date: 22-Oct-2012
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Remember the rumors of a new 